The famous Borgia Pearl, an important treasure with a history of bringing murder and also misery to its owner considering that the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But eventually the gem is swiped, because of an error on Holmes' component, and also shortly after that, a series of dreadful murders begin, the murderer leaving his victims with their spinal columns broke as well as bordered by a mass of smashed china.